How do you know that diarrhea is hereditary?
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Because it runs in my family
It runs in your genes.
The joke “Did you know that diarrhea is hereditary? It runs in your genes” is a pun that plays on the double meaning of the word “runs” and the homophonic relationship between “genes” and “jeans”. Diarrhea is often described colloquially as “the runs” due to its liquid consistency. The punchline humorously suggests that diarrhea can be passed down genetically (hereditary) and also makes a visual joke about it “running” in one’s “jeans” (pants), implying a messy accident.